10 Best Gaming Mice With Side Buttons in 2026 for MMO, MOBA, and FPS Play

The best gaming mouse with side buttons can put abilities, macros, media controls, and essential shortcuts within reach without forcing you back to the keyboard. The right layout depends on your games, hand size, grip, and preference for wired or wireless play.

We compared 10 options ranging from versatile two-button designs to MMO mice with large programmable side panels. Use the guide below to narrow your choices by comfort, customization, sensor performance, and overall value.

Best 10 Gaming Mouse with Side Buttons Picks for 2026

Customizable Control Pick – Logitech G502 HERO

The Logitech G502 HERO is a practical gaming mouse with side buttons for players who want extensive controls, adjustable weight, and precise wired tracking. Its 11 programmable buttons and dual-mode scroll wheel suit a wide range of PC gaming setups.

Best For: Right-handed PC gamers who prefer a customizable wired mouse with adjustable weight and abundant controls.

Pros:

• 11 programmable buttons provide flexible game and shortcut control.
• HERO sensor supports tracking up to 25,600 DPI without smoothing, filtering, or acceleration.
• Five removable 3.6 g weights allow personalized balance.
• LIGHTSYNC RGB lighting and a dual-mode hyper-fast scroll wheel add customization.

Cons:

• Wired design limits cable-free setup flexibility.
• Right-hand orientation may not suit left-handed users.

The G502 HERO stands out when precise tracking and physical customization matter more than wireless convenience. It is a strong fit for players who want many programmable controls in a familiar, feature-rich wired design.

Long-Battery Wireless Pick – Razer Basilisk V3 X HyperSpeed

The Razer Basilisk V3 X HyperSpeed is a gaming mouse with side buttons designed for players who want wireless freedom, ergonomic comfort, and programmable controls. It supports both low-latency HyperSpeed Wireless and Bluetooth for different gaming and everyday-use needs.

Best For: Right-handed gamers and productivity users who want long battery life and dual wireless connectivity.

Pros:

• Nine programmable controls support macros, shortcuts, and custom commands.
• HyperSpeed Wireless and Bluetooth provide flexible connectivity.
• Battery life is rated up to 285 hours wirelessly or 535 hours over Bluetooth.
• 18,000 DPI optical sensor and 1000 Hz polling rate support responsive tracking.

Cons:

• Uses a replaceable AA battery rather than an integrated rechargeable battery.
• Right-hand design is not intended for left-handed users.

This Basilisk model is a sensible choice for users who want a wireless gaming mouse without frequent battery interruptions. Its nine controls offer useful customization while its Bluetooth mode extends battery life for general use.

MMO Button-Heavy Value – Redragon M908 MMO Mouse

The Redragon M908 is a gaming mouse with side buttons built for MMO players who need a large command layout. It combines 12 programmable side buttons with 18 total programmable buttons, adjustable weights, RGB lighting, and wired USB connectivity.

Best For: MMO players who want extensive side-button access and multiple onboard profiles at a value-oriented price point.

Pros:

• 12 programmable side buttons and 18 total buttons support complex command setups.
• Five memory profiles make it easier to switch between configurations.
• Eight removable 2.4 g weights allow weight tuning.
• Up to 12,400 DPI, a 1000 Hz polling rate, and a Pixart PAW3327 sensor support responsive control.

Cons:

• The many side buttons may require an adjustment period.
• Wired construction does not provide wireless flexibility.
• Mac support is listed for normal use, while programmable functions are intended for Windows.

The M908 is especially compelling for MMO hotbars, macros, and games that benefit from numerous thumb-accessible commands. Its substantial button count and profile storage prioritize function over a minimalist design.

Most Versatile MMO Layout – Razer Naga V3 Pro

The Razer Naga V3 Pro is a gaming mouse with side buttons that can adapt to different genres through three swappable magnetic side plates. With 2-, 6-, or 12-button layouts, wireless and wired connectivity, and up to 23 listed buttons, it supports both MMO-heavy control schemes and simpler setups.

Best For: Right-handed PC gamers who want one mouse that can switch between MMO, MOBA, FPS, and everyday layouts.

Pros:

• Swappable 2-, 6-, and 12-button side plates provide genre-specific layouts.
• HyperSpeed Wireless, Bluetooth, and USB-C wired modes offer flexible connectivity.
• Focus Pro sensor supports up to 50,000 DPI, 930 IPS, and 90G acceleration.
• Battery life is rated up to 155 hours wirelessly or 280 hours over Bluetooth.

Cons:

• Full customization is available on Windows, while macOS supports core functions and onboard settings.
• Wireless charging accessories are sold separately.
• Its extensive customization may be more than casual users need.

The Naga V3 Pro is the most adaptable option in this group because its side-button configuration can change with the game. It is a strong investment for players who regularly move between genres and want both wireless convenience and a wired fallback.

Classic Wired Value – Redragon M602

The Redragon M602 is a practical pick if you want a gaming mouse with side buttons, adjustable sensitivity, and programmable controls without moving to a wireless setup. Its ergonomic right-handed shape and RGB lighting add flexibility for everyday gaming and work.

Best For: Budget-minded PC gamers who want customizable wired controls and RGB lighting.

Pros:

• Adjustable sensitivity up to 7,200 DPI
• Programmable buttons, remapping, and macro editing through software
• Ergonomic right-handed design with seven RGB modes and effects

Cons:

• Wired-only USB connectivity limits desk flexibility
• Right-hand orientation may not suit left-handed users
• Customization requires downloading the Redragon software

With eight buttons and a proven, durable design, the M602 is a straightforward choice for players who need useful side controls and adjustable tracking at an accessible price.

Premium MMO Control – ASUS ROG Spatha X

The ASUS ROG Spatha X is built for players who need a gaming mouse with side buttons for complex MMO and MOBA commands. It combines six strategically placed side buttons with wireless or USB-C wired operation, high-resolution tracking, and extensive customization.

Best For: MMO and MOBA players who want premium multi-button control with wireless flexibility.

Pros:

• Twelve programmable buttons, including six side buttons
• 2.4GHz wireless and USB-C wired modes
• 19,000 DPI sensor with 1,000 Hz polling in both modes
• Replaceable switches, charging dock, and up to 67 hours of battery life with RGB off

Cons:

• Large right-handed design may not fit every hand or grip
• Premium feature set may be excessive for casual users
• Designed for Windows 10 and Windows 11 PCs

The Spatha X stands out when side-button access and long-session customization matter most. Its hot-swappable switches and dual-mode connectivity also make it a more adaptable long-term investment.

Maximum Button Customization – UtechSmart Venus Pro

The UtechSmart Venus Pro targets MMO players who want a gaming mouse with side buttons and extensive on-board customization. It provides 12 thumb-accessible side buttons, adjustable DPI up to 16,400, five profiles, RGB lighting, and removable weights for tuning the feel.

Best For: Right-handed MMO players who rely on many macros, profiles, and adjustable weight.

Pros:

• Twelve programmable side buttons with macro and profile support
• Adjustable sensitivity from 200 to 16,400 DPI
• Five custom profiles and configurable RGB lighting
• Eight removable 2.4-gram weights and textured ergonomic grip

Cons:

• Wired USB design offers no wireless option
• Large number of side buttons may take time to learn
• Windows-focused compatibility may limit users on other systems

For MMO command-heavy layouts, the Venus Pro offers unusually broad control and personalization. Its angled side-button array, profiles, and adjustable weight make it especially suited to players willing to configure their mouse carefully.

Best for MMO Button Control – Corsair Scimitar RGB Elite

The Corsair Scimitar RGB Elite is a wired gaming mouse with side buttons designed for MMO and MOBA players who need fast access to frequent actions and complex macros. Its 12-button thumb panel can be repositioned to better match your grip, while the 18,000 DPI optical sensor supports precise, customizable tracking.

Best For: MMO and MOBA players who want a large, adjustable side-button grid and a durable wired design.

Pros:

• 17 programmable buttons support frequent actions and complex macros.
• Key Slider system repositions the 12 side buttons for a more comfortable fit.
• 18,000 DPI PixArt PMW3391 sensor offers adjustable tracking in 1 DPI steps.
• 50-million-click Omron switches, a sturdy scroll wheel, and braided cable support long-term use.

Cons:

• Wired connectivity may be less convenient than a wireless mouse.
• The extensive button layout is geared toward right-handed MMO and MOBA use rather than minimalist setups.

Choose the Scimitar RGB Elite if button access and layout adjustment matter more to you than a lightweight or wireless design. Its contoured right-handed shape and finger rest add support during extended sessions.

Best Wireless Flexibility – SM809 Pro Tri-Mode MMO Mouse

The SM809 Pro is a wireless gaming mouse with side buttons that combines 2.4GHz wireless, Bluetooth 5.0, and USB-C wired modes. It offers 16 programmable buttons, interchangeable magnetic side panels, and a 24,000 DPI PAW3311 optical sensor for players who want flexible controls across gaming and everyday devices.

Best For: Right-handed MMO players who want customizable side-button layouts, multi-device connectivity, and rechargeable wireless use.

Pros:

• Tri-mode connectivity supports 2.4GHz wireless, Bluetooth 5.0, and USB-C wired operation.
• Four magnetic side plates allow a compact three-button layout or a nine-button thumb grid.
• All 16 buttons are programmable for macros, hotkeys, and workflow shortcuts.
• Rechargeable 1,000mAh battery supports wireless use and charging while playing.

Cons:

• Its ergonomic shape is designed for right-handed users.
• Some configuration features require access to the web-based driver.

The SM809 Pro stands out when you need one gaming mouse with side buttons for multiple devices and play styles. Its swappable panels make the control layout more adaptable than a fixed MMO grid.

Best for Weight Tuning – Redragon M901K MMO Mouse

The Redragon M901K is a wired gaming mouse with side buttons built for players who want extensive remapping and a customizable feel. It provides 19 programmable buttons, including 12 side buttons, five memory profiles, adjustable DPI and polling rate, and eight removable weights for balance tuning.

Best For: PC gamers who want a highly configurable MMO mouse with adjustable weight and multiple stored profiles.

Pros:

• 19 programmable buttons provide extensive macro and shortcut control.
• Five memory profiles help save settings for different games or scenarios.
• Eight removable 2.4-gram weights allow personalized balance and feel.
• Adjustable 100-12,400 DPI, 125-1,000Hz polling rate, and RGB lighting offer customization.

Cons:

• USB-only wired connectivity limits cable-free flexibility.
• Its many buttons and removable weights may be more than casual players need.
• Customization software must be downloaded from RedragonZone.

The M901K is a practical choice when button count and physical tuning are your priorities. It is especially well suited to players who switch between games and want profiles and weight adjustments to match each setup.

How We Picked the Best Gaming Mouse with Side Buttons

We focused on the features that matter most during extended gaming sessions: side-button placement, programmable controls, sensor resolution, connection type, software support, ergonomics, and weight adjustment. The selection includes wired and wireless models, compact layouts for general gaming, and high-button-count designs for MMO and MOBA players.

Specifications such as DPI are useful for understanding adjustment range, but they do not determine a mouse’s overall quality. Button feel, tracking consistency, comfort, and the ability to save useful profiles are often more important in everyday use.

Quick Comparison

Best For	Look For	Recommended Style
General gaming	Two to six accessible side buttons	Versatile ergonomic mouse
MMO and RPGs	Large programmable side grid	12-button or higher layout
MOBA games	Quick-access buttons and solid grip	Moderate button count
Competitive FPS	Low weight, reliable tracking, minimal button clutter	Streamlined design
Flexible setups	Wireless, wired, or multi-mode connectivity	Tri-mode or low-latency wireless model

Key Buying Factors for a Gaming Mouse with Side Buttons

Button Layout and Programming

Count the buttons you will actually use rather than choosing the highest number automatically. Two or three side buttons can be ideal for shooters, while MMO players may benefit from 12 or more controls. Check whether the software supports remapping, macros, application profiles, and onboard memory.

Comfort and Hand Fit

A mouse should support your palm without forcing your fingers into awkward positions. Consider hand size, preferred grip, thumb placement, and total weight. A crowded side panel can improve access but may also cause accidental presses if the buttons are too close together.

Sensor and Performance

Look for consistent tracking, adjustable sensitivity, and a polling rate suited to your setup. Extremely high DPI ratings are not essential for most players; stable movement and dependable clicks matter more.

Wired Versus Wireless

Wired models usually offer simple plug-and-play use and avoid battery management. Wireless mice provide a cleaner desk and greater freedom, while tri-mode models add flexibility through Bluetooth, 2.4GHz wireless, and wired operation. Confirm battery life and charging options before buying.

Software, Compatibility, and Value

Verify that the configuration software supports your operating system and that the mouse works with your preferred games. Also consider warranty coverage, replacement skates, cable quality, and whether included features justify the price.

Who Should Buy Which Gaming Mouse with Side Buttons?

Choose a streamlined model if you mainly play FPS games or want a lighter, less distracting design. A mid-button ergonomic mouse is the best all-purpose choice for players who need shortcuts without a learning curve. MMO and RPG players should prioritize a comfortable multi-button side grid, profile support, and clear button separation. If you switch between devices or dislike cable clutter, choose a wireless or tri-mode model. Finally, prioritize adjustable weight only if you know you prefer a heavier or more balanced mouse; otherwise, a simpler fixed-weight design may offer better value.